Medtronic, Inc. operates as a medical technology company. It offers implantable cardiac pacemakers, eternal defibrillators, inferior turbinate surgery products, and continuous glucose monitoring device. The company was founded by Earl E. Bakken and Palmer J. Hermundslie on April 29, 1949 and is headquartered in Minneapolis, MN.

Edwards Lifesciences Corp. engages in patient-focused medical innovations for heart disease and critical care monitoring. Its products are categorized into four main areas: Transcatheter Aortic Valve Replacement, Transcatheter Mitral and Tricuspid Therapies, Surgical Structural Heart, and Critical Care. It operates through the following geographical segments: United States, Europe, Japan, and Rest of World. The company was founded by Miles Lowell Edwards in 1958 and is headquartered in Irvine, CA.

Opus Medical Therapies is developing transcatheter mitral and tricuspid valve replacement products for patients undergoing mitral and tricuspid valve disease. It is focused on addressing the challenging mitral regurgitation market.

Cardiac Pacemakers, Inc.(CPI), doing business as Guidant Cardiac Rhythm Management, manufactured implantable cardiac rhythm management devices, such as pacemakers and defibrillators. It also sold insulin pumps controlled by microprocessors and various equipments to regulate heart rhythm. In addition, Cardiac Pacemakers, Inc. developed therapies for the treatment of irregular heartbeats. The company was founded in 1971 and is based in St. Paul, Minnesota. Cardiac Pacemakers, Inc. operates as a subsidiary of Boston Scientific Corporation.

4C Medical Technologies is a medical device company that develops minimally invasive therapies for structural heart disease. It preserves the native mitral valve and left ventricle, eliminating known issues associated with transcatheter mitral valve replacement technologies that rely on placement and fixation in the native mitral annulus and left ventricle. It was founded in 2015 and headquartered in Maple Grove, Minnesota.

Biotronik (Biotronik SE & Co. KG; Biotronik Worldwide) is a privately held multinational biomedical technology company headquartered in Berlin, Germany. The company offers complete solutions for diagnosis, treatment, and therapy support in the areas of cardiac rhythm management, electrophysiology and vascular intervention. In the area of cardiac rhythm management, Biotronik Home Monitoring® uses telemonitoring technology to provide doctors with up-to-date information for implant patients.

V-Wave Ltd. is a privately held company with offices in Israel and the US. The company is focused on developing percutaneous implantable devices for treating patients with Chronic Heart Failure (HF). V-Wave’s vision is to help patients who remain with disabling symptoms or need hospitalization despite optimized medical treatment. V-Wave has developed a proprietary interatrial shunt intended to relieve symptoms, reduce hospitalization, increase exercise capacity and improve the overall quality of life. The original concept and development started in Israel with a talented team of engineers and medical scientists. The company’s senior management has decades of experience successfully developing, clinically testing and bringing to market multiple implantable cardiovascular devices.

Pacesetter, Inc., a subsidiary of Abbott Laboratories, is a company headquartered in the United States that manufactures, and distributes cardiovascular and implantable neuro stimulation medical devices.

Cardiovalve is a medical device company developing a transfemoral mitral valve replacement system. The flagship Cardiovalve system is the first one designed to replace the mitral valve using a transfemoral system. It is designed from the bottom up for transfemoral/transseptal delivery with femoral venous access. Cardivalve approach offers significant benefits, including a short profile for minimal protrusion to the left ventricle, minimizing interference in the cardiac blood flow and increased safety. It is currently evaluating the safety and performance of its system in clinical studies and it will seek EU and US approval.

BackBeat Medical Inc. is a medical technology company founded in 2010 to develop novel cardiac stimulation-based therapies for hypertension and heart failure. BackBeat has developed a patented cardiac pacing-based treatment for hypertension (HTN) called programmable hypertension control (PHC) therapy. PHC is comprised of proprietary pacing algorithms that can be readily incorporated into standard pacemakers using standard leads and standard lead placement and thus has broad applicability. PHC offers a new potent device-based HTN therapeutic alternative potentially opening up a large market to treat HTN patients, particularly HTN patients who already have or require a pacemaker. Clinical results generated to date using BackBeat’s own Moderato™ pacemaker incorporating PHC algorithms demonstrate that this therapy has a substantial and sustained therapeutic effect on blood pressure as determined by both in-office cuff measurements (average reduction of 24 mmHg from baseline) and 24-hour ambulatory measurements (average reduction of 14 mmHg from Baseline) with clinical follow up extending past two years in certain patients. BackBeat's PHC therapy is protected by an extensive global patent portfolio.

Cephea Valve Technologies, Inc. provides catheter delivered mitral valve regurgitation products/heart valves for the treatment of coronary artery disease in patients. It offers catheter based therapies, such as balloons and stents for aortic valves replacements. The company was incorporated in 2011 and is based in San Jose, California.

Tendyne Holdings, Inc. is a clinical stage medical device company focused on the development of minimally invasive therapies for the treatment of mitral regurgitation. Mitral regurgitation is a condition that afflicts hundreds of thousands of individuals worldwide every year. Formed in 2010, their first product concept is a transcatheter mitral valve replacement prosthesis for the treatment of mitral regurgitation. The intent is for the valve to be deployed and secured with no disruption to the native mitral annulus while preserving the sub-valvular apparatus. Placement of the valve is intended to be completed transapically in a simple procedure where the implanting physician is able to re-position, remove, and re-deploy their valve throughout the procedure.

Pipeline Medical Technologies, Inc. develops transcatheter device for heart surgical treatments. The company was founded by Steven Bolling and is headquartered in Santa Rosa, CA.

Part of LifeTech Scientific Corp., Lifetech Scientific (Shenzhen) Co. Ltd. is a Chinese company located in Shenzhen that manufactures medical devices. On July 06, 2004 ATC Technology Corp. (Arizona) acquired Lifetech Scientific (Shenzhen) Co. Ltd.

Chuangling Heart Rhythm Management Medical Devices researches and manufactures medical devices for cardiac rhythm disease management. The company also provides corresponding technical services and consulting, as well as sales and import and export of medical devices. Chuangling Heart Rhythm Management Medical Devices was founded in 2014 and is headquartered in Shanghai, China.

Kardium is a technology pioneer working to advance medical device technology in the diagnosis and treatment of atrial fibrillation. Kardium was founded in 2007 and has built an outstanding team with a track record of excellence in medicine, business, and engineering. We have hired the best engineers, medical researchers and production staff and have been working with a team of top medical advisors to develop the Globe mapping and ablation system. The Globe system has been entirely developed by the team at Kardium and provides a complete system to assist in the diagnosis and treatment of atrial fibrillation. Kardium is based in Vancouver, Canada, and has consistently ranked as one of the top companies to work for in British Columbia.

Twelve, Inc. is a holding company, which engages in the operation as an investment fund for a medical device incubator. It specializes on funding and developing medical device inventions. The company focuses on medical and biotech ventures. The company was founded in 2009 and is headquartered in Redwood City, CA.