Evalve, Inc. engages in the design, development, manufacture, and marketing of devices that enable the repair of cardiac valves. It provides a non-surgical mitral valve repair system consisting of a steerable guide catheter, a clip delivery system, and an implant device that is used by interventional cardiologists to reduce mitral regurgitation. The company was incorporated in 1999 and is based in Menlo Park, California.

Edwards Lifesciences Corp. engages in patient-focused medical innovations for heart disease and critical care monitoring. Its products are categorized into four main areas: Transcatheter Aortic Valve Replacement, Transcatheter Mitral and Tricuspid Therapies, Surgical Structural Heart, and Critical Care. It operates through the following geographical segments: United States, Europe, Japan, and Rest of World. The company was founded by Miles Lowell Edwards in 1958 and is headquartered in Irvine, CA.

NeoChord is a medical device company that has developed a proprietary device that allows mitral valve repair to be performed on a beating heart through a 2 to 3-inch incision between the ribs in patients with severe, degenerative mitral valve regurgitation. In contrast, most mitral valve repair procedures are performed through a 3 to 10-inch chest incision (sternotomy) which involves cutting through the sternum, opening the rib cage, stopping the heart and placing the patient on bypass. Founded in 2007 and is based in St. Louis Park, MN.

Part of Abbott Laboratories, St. Jude Medical, Cardiology Division, Inc. is a company headquartered in St. Paul, MN. The firm develops and commercializes minimally invasive cardiovascular and neurovascular medical devices. It was founded by Paul R. Buckman. Lisa D. Earnhardt is currently the CEO of the company.

CoreMedic was initiated in 2012 as a spin-out of the Heart Center of University of Bern, Switzerland, in order to develop an innovative treatment concept for mitral valve regurgitation (MR). The initiators of CoreMedic had a simple but challenging idea: to combine the least invasive treatment option for MR, replacement of mitral chords, and the least invasive operational procedure into one new system: ChordArt. In 2017, the development of ChordArt had progressed towards first use in a human trial, enabling CoreMedic to attract institutional financing. The company moved to RIZ-innovation center at Radolfzell, Germany, located at Lake Constance close to the Swiss border within the leading medical technology cluster of Tuttlingen, Germany. Following successful conclusion of the first human trial of ChordArt in 2018, and two-year data confirming the powerful treatment effect of the ChordArt implant in patients with severe MR, CoreMedic GmbH is tirelessly working to make the ChordArt TMVr system available to patients. ​

Ancora Heart is dedicated to helping people with heart failure feel better and live longer. Ancora Heart developed the AccuCinch System, an investigational therapy designed to repair the enlarged left ventricle targeting the underlying cause of heart failure. The AccuCinch heart failure treatment was created to benefit the millions of patients who otherwise have no minimally invasive option available to them.

Boston Scientific Scimed, Inc. develops, manufactures, and markets medical devices used principally to treat cardiovascular disease.

Guided Delivery Systems, Inc. operates as a medical device company. The company develops technology for percutaneous treatment of mitral valve regurgitation. Guided Delivery Systems, Inc. was incorporated in 2001 and is based in Santa Clara, California.

Traverse Partners LLC, part of Hovnanian Enterprises, Inc., is a company headquartered in Mooresville, NC, that provides investment advice. It was founded by Jeff Janer.

Medtentia International Ltd. Oy is a holding company that develops solutions for mitral valve repair based on its proprietary helix ring concept. It is a medical technology company that creates solutions for cardiac interventions. It provides proprietary, helix-shaped products to address the unmet need in cardiac surgery. The company was founded by Dan Mogren and Olli U. Ker��nen in 2002 by Olli Ker��nen and is headquartered in Espoo, Finland.

St. Jude Medical, Inc. was an American global medical device company headquartered in Little Canada, Minnesota, U.S., a suburb of Saint Paul. The company had more than 20 principal operations and manufacturing facilities worldwide with products sold in more than 100 countries. Its major markets include the United States, Europe, Latin America and Asia-Pacific. The company was named after Jude the Apostle, the patron saint of lost causes.

Advanced Cardiovascular Systems, Inc. develops and manufactures cardiovascular medical products. It operates as a subsidiary of Abbott Laboratories. Its medical devices help patients with heart diseases in returning to active and productive lives and physicians for improving patient management and clinical outcomes. Advanced Cardiovascular Systems, Inc. is based in Santa Clara, California. it is currently known as Abbott Cardiovascular Systems.

Hangzhou Valgen Medtech Co., Ltd. is a company headquartered in Hangzhou, China, that develops and manufactures novel mitral valve repair systems. The firm was founded in 2015. Ting Chao Zhang is currently the CEO of the company.

Medtronic Vascular designs and develops technologies for coronary, peripheral, and neurovascular indications. The company’s products include S7 Zipper MX Coronary Stent System, Clo-Sur PAD Nonwoven Hydrophilic Wound Dressing, Launcher Coronary Guide Catheter, and Stormer Over-the-Wire Balloon Dilatation Catheter. The company also offers Bridge Assurant Balloon-Expandable Stent Delivery System, GuardWire Plus Temporary Occlusion and Aspiration System, and S660 Coronary Stent. Medtronic Vascular was incorporated in 1991 and is based in Santa Rosa, California. As of January 29, 1999, Medtronic Vascular operates as a subsidiary of Medtronic.

Cephea Valve Technologies, Inc. provides catheter delivered mitral valve regurgitation products/heart valves for the treatment of coronary artery disease in patients. It offers catheter based therapies, such as balloons and stents for aortic valves replacements. The company was incorporated in 2011 and is based in San Jose, California.

Half Moon Medical, Inc. engages in the provision of health care services. The company was founded in 2017 and is headquartered in Menlo Park, CA.

Claret Medical, Inc. develops a series of cerebral vascular protection systems for transcatheter aortic valve implantation, surgical, and other interventional procedures. The company’s products include Claret Medical Montage, a dual filter system and percutaneously delivered embolic protection device to capture and remove debris disloged during vascular procedures; and small (6F) catheters that are inserted into the patient's right arm to protect the patient’s brain during interventional procedures where embolic debris might be released. It offers its products for use as an embolic protection system to capture and remove embolic material (thrombus/debris) that may enter the cerebral vascular system during endovascular procedures. The company was incorporated in 2009 and is based in Santa Rosa, California.

Elixir Medical Corp. develops innovative products that combine state of the art medical devices with advanced pharmaceuticals. Its next-generation drug-eluting stent systems and bioresorbable coronary scaffold are designed to optimize localized drug delivery to provide safe and effective treatments for cardiovascular patients. The company was founded in 2005 and is headquartered in Sunnyvale, CA.

Part of MOH Holdings Pte Ltd., Singapore Health Services Pte Ltd. is a Singaporean company located in Singapore. The firm provides medical services. Ivy Ng is the CEO, in this role since 2012.