Edwards Lifesciences Corp. engages in patient-focused medical innovations for heart disease and critical care monitoring. Its products are categorized into four main areas: Transcatheter Aortic Valve Replacement, Transcatheter Mitral and Tricuspid Therapies, Surgical Structural Heart, and Critical Care. It operates through the following geographical segments: United States, Europe, Japan, and Rest of World. The company was founded by Miles Lowell Edwards in 1958 and is headquartered in Irvine, CA.

Medtronic, Inc. operates as a medical technology company. It offers implantable cardiac pacemakers, eternal defibrillators, inferior turbinate surgery products, and continuous glucose monitoring device. The company was founded by Earl E. Bakken and Palmer J. Hermundslie on April 29, 1949 and is headquartered in Minneapolis, MN.

Part of Abbott Laboratories, St. Jude Medical, Cardiology Division, Inc. is a company headquartered in St. Paul, MN. The firm develops and commercializes minimally invasive cardiovascular and neurovascular medical devices. It was founded by Paul R. Buckman. Lisa D. Earnhardt is currently the CEO of the company.

St. Jude Medical, Inc. was an American global medical device company headquartered in Little Canada, Minnesota, U.S., a suburb of Saint Paul. The company had more than 20 principal operations and manufacturing facilities worldwide with products sold in more than 100 countries. Its major markets include the United States, Europe, Latin America and Asia-Pacific. The company was named after Jude the Apostle, the patron saint of lost causes.

W. L. Gore & Associates has made its name by creating innovative, technology-driven solutions, from medical devices that treat aneurysms to high-performance GORE‑TEX® fabrics. A privately held company with annual sales of more than $3 billion, Gore is committed to perpetuating its 50-plus year tradition of product innovation. Gore focuses its efforts in four main areas: electronics, fabrics, industrial and medical products. The company’s electronic products division develops and manufactures high-performance copper and optical signal transmission products. Gore’s fabrics provide protection from the elements and enable wearers to remain comfortable across a broad range of activities and conditions. The products made by Gore’s industrial division meet diverse contamination control and processing challenges throughout industry. Implants from the medical division provide creative healing solutions to complex medical problems. Today, Gore employs more than 10,000 employees, called associates, with manufacturing facilities in the United States, Germany, the United Kingdom, Japan and China, and sales offices around the world.

Tendyne Holdings, Inc. is a clinical stage medical device company focused on the development of minimally invasive therapies for the treatment of mitral regurgitation. Mitral regurgitation is a condition that afflicts hundreds of thousands of individuals worldwide every year. Formed in 2010, their first product concept is a transcatheter mitral valve replacement prosthesis for the treatment of mitral regurgitation. The intent is for the valve to be deployed and secured with no disruption to the native mitral annulus while preserving the sub-valvular apparatus. Placement of the valve is intended to be completed transapically in a simple procedure where the implanting physician is able to re-position, remove, and re-deploy their valve throughout the procedure.

Medtronic Vascular designs and develops technologies for coronary, peripheral, and neurovascular indications. The company’s products include S7 Zipper MX Coronary Stent System, Clo-Sur PAD Nonwoven Hydrophilic Wound Dressing, Launcher Coronary Guide Catheter, and Stormer Over-the-Wire Balloon Dilatation Catheter. The company also offers Bridge Assurant Balloon-Expandable Stent Delivery System, GuardWire Plus Temporary Occlusion and Aspiration System, and S660 Coronary Stent. Medtronic Vascular was incorporated in 1991 and is based in Santa Rosa, California. As of January 29, 1999, Medtronic Vascular operates as a subsidiary of Medtronic.

Twelve, Inc. is a holding company, which engages in the operation as an investment fund for a medical device incubator. It specializes on funding and developing medical device inventions. The company focuses on medical and biotech ventures. The company was founded in 2009 and is headquartered in Redwood City, CA.

Traverse Partners LLC, a subsidiary of Hovnanian Enterprises, Inc., is a company headquartered in Mooresville, NC. The firm provides investment advice. It was founded by Jeff Janer.

4C Medical Technologies is a medical device company that develops minimally invasive therapies for structural heart disease. It preserves the native mitral valve and left ventricle, eliminating known issues associated with transcatheter mitral valve replacement technologies that rely on placement and fixation in the native mitral annulus and left ventricle. It was founded in 2015 and headquartered in Maple Grove, Minnesota.

Boston Scientific Scimed, Inc. develops, manufactures, and markets medical devices used principally to treat cardiovascular disease.

JenaValve Technology GmbH develops and manufactures transcatheter valve implantation systems for transapical and transfemoral implantation. The firm offers a therapeutic alternative to surgical aortic valve replacement for high-risk patients suffering from aortic heart valve stenosis. The company was founded by Markus Ferrari, Volker Guyenot and Hans-Reiner Figulla in 2006 and is headquartered in Munich, Germany.

Caisson Interventional is a privately held clinical-stage medical device company focused on the design, development, and clinical evaluation of a novel percutaneous mitral valve replacement system.

AorTx, Inc. develops device solutions for percutaneous replacement of the aortic valve in the United States. Its devices cover the procedural solution for heart valve therapy from the implant to delivery and deployment of the valve. AorTx, Inc. was formerly known as CardiacMD, Inc. The company is based in Redwood City, California. As of November 15, 2007, AorTx, Inc. operates as a subsidiary of Hansen Medical, Inc.

Colibri Heart Valve is a privately held medical device company based in Broomfield, CO that researches and develops novel heart valve technologies. It has developed a pre-mounted, pre-crimped, and pre-packaged, ready-for-use transcatheter aortic valve implantation (TAVI) device called the Colibri TAVI System. The company's technology is a culmination of over 10 years of research and development by Colibri’s founders, Dr. David Paniagua and Dr. R. David Fish into the tissue, valve design, frame, and delivery catheter. Its tissue processing method produces extremely strong, durable, and biocompatible tissue. The proprietary tissue enables loading, crimping, and packaging of the Colibri valve at manufacture, making in-procedure valve rinsing and loading at the time of use unnecessary. The Colibri TAVI System is designed to be shipped ready-for-use. Colibri’s corporate headquarters and pre-commercialization facilities are located in Broomfield, Colorado with R&D located in Houston, Texas. Colibri technology is protected by both trade secrets and issued and pending patent applications with priority claims and content dating back to January 4, 2002.

Cardiovalve is a medical device company developing a transfemoral mitral valve replacement system. The flagship Cardiovalve system is the first one designed to replace the mitral valve using a transfemoral system. It is designed from the bottom up for transfemoral/transseptal delivery with femoral venous access. Cardivalve approach offers significant benefits, including a short profile for minimal protrusion to the left ventricle, minimizing interference in the cardiac blood flow and increased safety. It is currently evaluating the safety and performance of its system in clinical studies and it will seek EU and US approval.

CardiAQ Valve Technologies (CVT), a privately held company, is developing innovative approaches to heart valve replacement and is initially focused on transcatheter mitral valve implantation (TMVI).

Part of Medtronic Plc, Medtronic Vascular Galway Unlimited Co. is a company headquartered in Dublin, Ireland. The firm manufactures and retails pharmaceutical products.